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Liver Research

A liver cell atlas to help understand how cells change, during liver disease development & progression

Liver diseases are one of the biggest health problems in the world and a leading cause of death. It is important to know the various functions of individual liver cells so that new treatment algorithms can be developed.   Modern scientific methods are now available to do just that. Using sophisticated practices, scientists from the […]

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Bioengineered livers for transplants: How close are we to success?

Liver bioengineering has been a hotbed of intense research in the past few decades. Ever since the concept of whole liver acellular scaffolds generated by perfusion decellularization was introduced, liver bioengineering has focused on making a success of bioengineered livers fit for liver transplants. Liver development is a stepwise process that includes distinct biological events. […]

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How liver stem cells help in liver regeneration

Under physiological conditions, cell turnover in the liver is very less, about one in 300 hepatocytes divide to maintain the liver mass. However, in response to simple injury such as partial hepatectomy, repair is mediated by proliferation of endogenous hepatocytes without need for any adjunctive repair pathways. But hepatocyte replication is compromised in conditions of […]

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Liver repopulation with cell transplantation: Provides hope of life for patients with end stage liver diseases.

Liver transplant has been at the forefront of clinical regenerative medicine. The remarkable ability of the liver to regenerate and the advent of living donor liver transplant came as a boon for patients with end stage liver disease. In recent times, liver donor shortages have fueled clinically viable alternative for liver repopulation by cell transplantation. […]

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Gene editing offers hope in halting fatty build up in the liver

Cholesterol is normally found in the blood and combines with proteins to travel through the bloodstream as lipoproteins. The liver makes most of the cholesterol in the body. The two forms of cholesterol are the “good” cholesterol or high density lipoprotein (HDL) and the “bad cholesterol, the low density lipoprotein (LDL). The loose terms, good […]

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Recent reports from “Livercon V” defining the status of liver disease in India

Prevalence of Hepatitis B virus is high among Indian tribal population Hepatitis B virus (HBV) infection is one of the important causes for chronic liver disease in India. The Union Health Ministry data of 2018 indicates an estimated four crore people were suffering from HBV in India. A recent study by a leading hepatologist, Dr […]

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Organs in a dish’ pave the way for personalized medicine in the gut and liver disease

Organoid systems are one of the most dramatic advancements in stem cell research. These are commonly known as “organs in a dish” because they are organ-like three-dimensional structures that mimic their corresponding organ in the lab and can literally be grown out of the petri dish. For the liver, the procedure can enable liver tissues […]

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New Lease of Life for Liver Research

A lot of research is been initiated to halt progression of liver damage to fibrosis and severe scarring of the liver called cirrhosis. However, funding such research has many challenges including a very high budget. In a new development, the collaboration between GE Healthcare and Takeda Group have announced that they will be combining efforts […]

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Scientists Identify 14 Genes Associated with Biliary Atresia Survival

Biliary atresia is the most common cause for persistent jaundice and pale stools after birth, despite phototherapy in infants. It is an abnormality wherein the bile ducts draining bile from the liver to the intestine are absent. This causes the bile to be trapped inside the liver, leading to inflammation and subsequent scarring of the […]

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